by Sophie Guinoiseau | Jan 23, 2023
Genetic and environmental animal models of autism reproduce the spectrum of the disease Summary Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing...
by Sophie Guinoiseau | Nov 21, 2022
Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia Summary COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial...
by Sophie Guinoiseau | Nov 16, 2022
Reconstructing rodent and human Neuronal Networks to model Neurodegenerative syndromes Summary Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for...
by Sophie Guinoiseau | Oct 12, 2022
Summary The timescale dynamics of epilepsies: from seconds to decades Continuous long-term recordings (months to years) in patients with epilepsy directly show that seizures are regulated not only in a circadian manner, but also on a much slower time scale (days to...
by Sophie Guinoiseau | Sep 28, 2022
Summary The developmental history of the molecular synaptic code controlling excitatory connectivity The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with...
