GLIA-GLIA AND GLIA-NEURON INTERACTIONS GROUP

Our group is interested in understanding the role of glial cells in the mammalian central nervous system and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS. We try to understand the role of glial cells in the mammalian central (CNS) and peripheral nervous systems (PNS), and the mechanisms by which glial cells and neurons interact to support normal sensory processing and perception. We are developing and using a set of interdisciplinary and complementary tools (electrophysiology, chemogenetics, 2-photon Ca2+ imaging, immunohistochemistry, biochemistry, and behavior) and approaches to selectively manipulate and monitor glial cell signaling and investigate its effects in synaptic transmission, plasticity, and memory underlying sensory processing. From these studies, we hope to resolve some glial cell functions, and open up entirely new areas of investigation and potential treatments of diseases. Indeed, astrocytes play a major role in many neurological disorders, and it has become clear that sensory perception, notably visual perception, touch and proprioception, are impaired in some of them.

Research topics
  • THEME 1: Roles of astrocyte and satellite glial cell signalingin synaptic transmission, plasticity, memory and sensory processing
  • THEME 2: Roles of astrocytes signaling satelliteglial cells in neuroinflammation: implications in neurodevelopmental (Schizophrenia and Autism) and neurodegenerative (Alzheimer’s disease, Parkinson’s disease, Friedreich’s Ataxia) diseases
  • THEME 3: Astrocytic – Microglia interactions

TEAM MEMBERS

Permanent researchers

Cendra AGULHON

Cendra AGULHON

CR, HDR CNRS

Team leader

Jacques STINNAKRE

Jacques STINNAKRE

DR CNRS

Consultant

Visiting scientists

Nicholas PRIEBE

Nicholas PRIEBE

Invited Pr U.Texas USA

Support staff

Sophie GUINOISEAU

Sophie GUINOISEAU

AI

Post docs, PhD and Master students

Elsie MOUKARZEL

Elsie MOUKARZEL

PhD student

Bruna RUBINO

Bruna RUBINO

PhD student

Pauline MERIAU

Pauline MERIAU

PhD student

Valentine TURPIN

Valentine TURPIN

M2 student

PUBLICATIONS ▼

Articles

GLIA-GLIA AND GLIA-NEURON INTERACTIONS GROUP

Our group is interested in understanding the role of glial cells in the mammalian central nervous system and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS. We try to understand the role of glial cells in the mammalian central (CNS) and peripheral nervous systems (PNS), and the mechanisms by which glial cells and neurons interact to support normal sensory processing and perception. We are developing and using a set of interdisciplinary and complementary tools (electrophysiology, chemogenetics, 2-photon Ca2+ imaging, immunohistochemistry, biochemistry, and behavior) and approaches to selectively manipulate and monitor glial cell signaling and investigate its effects in synaptic transmission, plasticity, and memory underlying sensory processing. From these studies, we hope to resolve some glial cell functions, and open up entirely new areas of investigation and potential treatments of diseases. Indeed, astrocytes play a major role in many neurological disorders, and it has become clear that sensory perception, notably visual perception, touch and proprioception, are impaired in some of them.

RESEARCH TOPICS ▼

Theme 1: Roles of astrocyte and satellite glial cell signalingin synaptic transmission, plasticity, memory and sensory processing

Theme 2: Roles of astrocytes signaling satelliteglial cells in neuroinflammation: implications in neurodevelopmental (Schizophrenia and Autism) and neurodegenerative (Alzheimer’s disease, Parkinson’s disease, Friedreich’s Ataxia) diseases

Theme 3: Astrocytic – Microglia interactions

TEAM MEMBERS

Permanent researchers

Cendra AGULHON

Cendra AGULHON

CR CNRS, HDR

Team leader

Jacques STINNAKRE

Jacques STINNAKRE

DR CNRS, Consultant

Visiting scientists

Nicholas PRIEBE

Nicholas PRIEBE

Invited PR U.Texas USA

Support staff

Sophie GUINOISEAU

Sophie GUINOISEAU

AI

Post docs, PhD & Master students

Elsie MOUKARZEL

Elsie MOUKARZEL

PhD student

Bruna RUBINO

Bruna RUBINO

PhD student

Pauline MERIAU

Pauline MERIAU

PhD student

Valentine TURPIN

Valentine TURPIN

M2 student

PUBLICATIONS ▼

Articles