PATHOPHYSIOLOGY OF PSYCHIATRIC DISORDERS GROUP

Research conducted by the Pathophysiology of Psychiatric Disorders team aims to answer two major questions : the Etiology of Depression, and the function of Dopamine in  the pathophysiology of schizophrenia.

Our fundamental and preclinical studies have identified new mechanisms contributing to individual vulnerability or resistance (resiliency) to depression and underlying the action of antidepressants. Ongoing projects aim to further elucidate the role of these novel systems in plasticity-related processes within the neural circuitry in normal and pathological conditions. We will also investigate whether certain of these systems constitute valid biomarkers in humans, to assess the efficacy of antidepressant therapies, and we are currently developing selective approaches to manipulate their activity in order to improve antidepressant efficacy.

Research topics
  • Theme 1: Etiology of depression
    – Development of biomarkers in humans to assess the efficacy of antidepressant therapies
  • Theme 2: Dopamine hypothesis and pathophysiology of schizophrenia
    – Dopamine transporter (DAT) interactome and proteome
    characterizing DA dynamics in cortical areas

TEAM MEMBERS

Permanent researchers

Eleni TZAVARA

Eleni TZAVARA

DR INSERM

Team leader
Bruno GIROS

Bruno GIROS

PR

Team leader
Stéphanie DE GOIS

Stéphanie DE GOIS

IR CNRS

Jorge DIAZ

Jorge DIAZ

MCF

Marie KÖRNER

Marie KÖRNER

DR CNRS

Visiting clinician

Jasmina MALLET

Jasmina MALLET

Clinician

Post docs, PhD and Master students

Victor GORGIEVSKI

Victor GORGIEVSKI

Post doc

Florian REBEILLARD

Florian REBEILLARD

PhD student

Sarah MESSAOUDENE

Sarah MESSAOUDENE

M2 student

PUBLICATIONS ▼

Articles

Chapters

  • Farrar WL, Körner M, Brini A, Harel-Bellan A, and Ferris D. Hematopoietic Growth-Factors Signal Transduction and Regulation of Gene Expression. Molecular Hematology, Chapter 14, Garland J - Eds. M. Dexter and J. Garland Elsvier Publishers, London, pp.379-410, 1989.
  • Farrar WL, Körner M, and Brini A. The role of Calcium in Cellular Proliferation. The Role of Calcium in Biological Systems, Farrar WL - Eds. L. Anghitevi, CRC Press Boca Raton Pb., pp.239-252, 1989.
  • Abehsira-Amar O, Jankovic DL, Körner M, and Thèze J. Influence of IL-4 on the induction of immunoglobulin secretion by BCAF-containing supernatant. Lymphocyte activation and Differentiation, Thèze J - Walter de Gruyter & Co., Berlin, 1988.
  • Ganellin CR, Boutenet ML, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, and Theobald CJ. Iodinated Ligands for detecting and characterizing Histamine H1 receptors. Proceedings of the 10th international symposium on Medicinal Chemistry, L Palosand, H Timmerman - Elsvier Publisher, 1988.
  • Garbarg M, Yeramian E, Korner M, Schwartz JC. Biochemical studies of cerebral H1-receptors. Frontiers in histamine research, Ganelin CR, Schwartz JC - Frontiers in histamine research. Oxford: Pergamon Press, pp.19-25, 1985.
  • Garbard M, Yeramian E, Körner M, and Schwartz J-C. Biochemical studies of cerebral H1-receptors. Frontiers in Histamine Research, CR Ganellin and J-C Schwartz - Pergamon Press (Oxford), pp.19-25, 1985.

PATHOPHYSIOLOGY OF PSYCHIATRIC DISORDERS GROUP

Research conducted by the Pathophysiology of Psychiatric Disorders team aims to answer two major questions : the Etiology of Depression, and the function of Dopamine in  the pathophysiology of schizophrenia.

Our fundamental and preclinical studies have identified new mechanisms contributing to individual vulnerability or resistance (resiliency) to depression and underlying the action of antidepressants. Ongoing projects aim to further elucidate the role of these novel systems in plasticity-related processes within the neural circuitry in normal and pathological conditions. We will also investigate whether certain of these systems constitute valid biomarkers in humans, to assess the efficacy of antidepressant therapies, and we are currently developing selective approaches to manipulate their activity in order to improve antidepressant efficacy.

RESEARCH TOPICS ▼

Theme 1: Etiology of depression
- Development of biomarkers in humans to assess the efficacy of antidepressant therapies
Theme 2: Dopamine hypothesis and pathophysiology of schizophrenia
- Dopamine transporter (DAT) interactome and proteome
characterizing DA dynamics in cortical areas

TEAM MEMBERS

Permanent researchers

Eleni TZAVARA

Eleni TZAVARA

DR INSERM

Team leader

Bruno GIROS

Bruno GIROS

PR

Team leader

Stéphanie DE GOIS

Stéphanie DE GOIS

IR CNRS

Jorge DIAZ

Jorge DIAZ

MCF

Marie KÖRNER

Marie KÖRNER

DR CNRS

Visiting clinician

Jasmina MALLET

Jasmina MALLET

Clinician

Post docs, PhD & Master students

Victor GORGIEVSKI

Victor GORGIEVSKI

Post doc

Florian REBEILLARD

Florian REBEILLARD

PhD student

Sarah MESSAOUDENE

Sarah MESSAOUDENE

M2 student

PUBLICATIONS ▼

Articles

Chapters

  • Farrar WL, Körner M, Brini A, Harel-Bellan A, and Ferris D. Hematopoietic Growth-Factors Signal Transduction and Regulation of Gene Expression. Molecular Hematology, Chapter 14, Garland J - Eds. M. Dexter and J. Garland Elsvier Publishers, London, pp.379-410, 1989.
  • Farrar WL, Körner M, and Brini A. The role of Calcium in Cellular Proliferation. The Role of Calcium in Biological Systems, Farrar WL - Eds. L. Anghitevi, CRC Press Boca Raton Pb., pp.239-252, 1989.
  • Abehsira-Amar O, Jankovic DL, Körner M, and Thèze J. Influence of IL-4 on the induction of immunoglobulin secretion by BCAF-containing supernatant. Lymphocyte activation and Differentiation, Thèze J - Walter de Gruyter & Co., Berlin, 1988.
  • Ganellin CR, Boutenet ML, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, and Theobald CJ. Iodinated Ligands for detecting and characterizing Histamine H1 receptors. Proceedings of the 10th international symposium on Medicinal Chemistry, L Palosand, H Timmerman - Elsvier Publisher, 1988.
  • Garbarg M, Yeramian E, Korner M, Schwartz JC. Biochemical studies of cerebral H1-receptors. Frontiers in histamine research, Ganelin CR, Schwartz JC - Frontiers in histamine research. Oxford: Pergamon Press, pp.19-25, 1985.
  • Garbard M, Yeramian E, Körner M, and Schwartz J-C. Biochemical studies of cerebral H1-receptors. Frontiers in Histamine Research, CR Ganellin and J-C Schwartz - Pergamon Press (Oxford), pp.19-25, 1985.