PATHOPHYSIOLOGY OF PSYCHIATRIC DISORDERS GROUP

Research conducted by the Pathophysiology of Psychiatric Disorders team aims to answer two major questions : the Etiology of Depression, and the function of Dopamine in the pathophysiology of schizophrenia.

Our fundamental and preclinical studies have identified new mechanisms contributing to individual vulnerability or resistance (resiliency) to depression and underlying the action of antidepressants. Ongoing projects aim to further elucidate the role of these novel systems in plasticity-related processes within the neural circuitry in normal and pathological conditions. We will also investigate whether certain of these systems constitute valid biomarkers in humans, to assess the efficacy of antidepressant therapies, and we are currently developing selective approaches to manipulate their activity in order to improve antidepressant efficacy.

Research topics

Theme 1: Etiology of depression
– Neural networks in vulnerability and resiliance to depression

Theme 2: Dopamine hypothesis and pathophysiology of schizophrenia
– Dopamine transporter (DAT) interactome and proteome
characterizing DA dynamics in cortical areas

– Functional diversity of dopaminoceptive Medium Spiny Neurons

Functional diversity of dopaminoceptive Medium Spiny Neurons

TEAM MEMBERS

Permanent researchers

Bruno GIROS

Team leader

Jorge DIAZ

MCF

Team leader

Stéphanie DE GOIS

IR CNRS

Elsa ISINGRINI

CR CNRS

Post docs, PhD and Master students

Déa SLAVOVA

PhD student

Gurvan LE LAY

M2 student

Maud BLAISE

M1 student

︾ PUBLICATIONS ︾

Articles

Orrico-Sanchez A, Chausset-Boissarie L, Alves de Sousa R, Coutens B, Rezai Amin S, Vialou V, Louis F, Hessani A, Dansette PM, Zornoza T, Gruszczynski C, Giros B, Guiard BP, Acher F, Pietrancosta N, Gautron S. Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression. Mol Psychiatry, 2020, 25 (6), pp.1245-1259.
Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N. LSP5-2157 a new inhibitor of vesicular glutamate transporters. Neuropharmacology, 2020, 164, pp.107902.
Laboute T, Gandía J, Pellissier LP, Corde Y, Rebeillard F, Gallo M, Gauthier C, Léauté A, Diaz J, Poupon A, Kieffer BL, Le Merrer J, Becker JA. The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs. Elife, 2020, 9.
Diaz J, Gérard X, Emerit MB, Areias J, Geny D, Dégardin J, Simonutti M, Guerquin MJ, Collin T, Viollet C, Billard JM, Métin C, Hubert L, Larti F, Kahrizi K, Jobling R, Agolini E, Shaheen R, Zigler A, Rouiller-Fabre V, Rozet JM, Picaud S, Novelli A, Alameer S, Najmabadi H, Cohn R, Munnich A, Barth M, Lugli L, Alkuraya FS, Blaser S, Gashlan M, Besmond C, Darmon M, Masson J. YIF1B mutations cause a post-natal neurodevelopmental syndrome associated with Golgi and primary cilium alterations. Brain, 2020, 143 (10), pp.2911-2928.
Hernandez G, Mahmoudi S, Cyr M, Diaz J, Blanchet PJ, Lévesque D. Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates. Mov Disord, 2019, 34 (5), pp.717-726.
Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET. Antidepressive effects of targeting ELK-1 signal transduction. Nat Med, 2018, 24 (5), pp.591-597.
Isingrini E, Guinaudie C, C Perret L, Rainer Q, Moquin L, Gratton A, Giros B. Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice. Sci Rep, 2017, 7 (1), pp.12432.
Mahar I, Labonte B, Yogendran S, Isingrini E, Perret L, Davoli MA, Rachalski A, Giros B, Turecki G, Mechawar N. Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Transl Psychiatry, 2017, 7 (7), pp.e1161.
Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. ENeuro, 2017, 4 (3).
Moinard C, Tliba L, Diaz J, Le Plénier S, Nay L, Neveux N, Cynober L, Raynaud-Simon A. Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway. Nutrition, 2017, 38, pp.9-12.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S. Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells. Front Cell Neurosci, 2017, 11, pp.140.
Emerit MB, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, Masson J, Boué-Grabot E, Darmon M. A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels. J Neurosci, 2016, 36 (5), pp.1456-70.
Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B. Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nat Neurosci, 2016, 19 (4), pp.560-3.
Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA. Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biol Psychiatry, 2016, 79 (11), pp.917-27.
Doly S, Shirvani H, Gäta G, Meye FJ, Emerit MB, Enslen H, Achour L, Pardo-Lopez L, Yang SK, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M, Marullo S. GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper. Mol Psychiatry, 2016, 21 (4), pp.480-90.
Herbin M, Simonis C, Revéret L, Hackert R, Libourel PA, Eugène D, Diaz J, de Waele C, Vidal PP. Dopamine Modulates Motor Control in a Specific Plane Related to Support. PLoS One, 2016.
Rocchetti J, Isingrini E, Dal Bo G, Sagheby S, Menegaux A, Tronche F, Levesque D, Moquin L, Gratton A, Wong TP, Rubinstein M, Giros B. Presynaptic D2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. Biol Psychiatry, 2015, 77 (6), pp.513-25.
Martel G, Simon A, Nocera S, Kalainathan S, Pidoux L, Blum D, Leclère-Turbant S, Diaz J, Geny D, Moyse E, Videau C, Buée L, Epelbaum J, Viollet C. Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice. Neurobiol Aging, 2015, 36 (2), pp.1013-28.
Alterio J, Masson J, Diaz J, Chachlaki K, Salman H, Areias J, Al Awabdh S, Emerit MB, Darmon M. Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture. Traffic, 2015, 16 (9), pp.978-93.
Khaled MA, Pushparaj A, Di Ciano P, Diaz J, Le Foll B. Dopamine D3 receptors in the basolateral amygdala and the lateral habenula modulate cue-induced reinstatement of nicotine seeking. Neuropsychopharmacology, 2014, 39 (13), pp.3049-58.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Isingrini E, Belzung C, Freslon JL, Machet MC, Camus V. Fluoxetine effect on aortic nitric oxide-dependent vasorelaxation in the unpredictable chronic mild stress model of depression in mice. Psychosom Med, 2012, 74 (1), pp.63-72.
Isingrini E, Belzung C, d’Audiffret A, Camus V. Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging. Am J Geriatr Psychiatry, 2011, 19 (4), pp.335-46.
Narboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R. Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology, 2011, 36 (12), pp.2538-50. (PDF)
Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM. Polarized Secretion of Lysosomes at the B Cell Synapse couples Antigen Extraction to Processing and Presentation. Immunity, 2011.
Pietrancosta N, Kessler A, Favre-Besse F-C, Triballeau N, Quentin T, Giros B, El Mestikawy S, Acher F C. Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorganic \& medicinal chemistry, 2010, 18, pp.6922--6933.
Isingrini E, Camus V, Le Guisquet AM, Pingaud M, Devers S, Belzung C. Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice. PLoS One, 2010, 5 (4), pp.e10404.
d’Audiffret AC, Frisbee SJ, Stapleton PA, Goodwill AG, Isingrini E, Frisbee JC. Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?. J Appl Physiol (1985), 2010, 108 (5), pp.1041-51.
Amilhon B, Lepicard E, Renoir T, Mongeau R, Popa D, Poirel O, Miot S, Gras C, Gardier AM, Gallego J, Hamon M, Lanfumey L, Gasnier B, Giros B, El Mestikawy S. VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. J Neurosci, 2010, 30 (6), pp.2198-210. (PDF)
Isingrini E, Desmidt T, Belzung C, Camus V. Endothelial dysfunction: A potential therapeutic target for geriatric depression and brain amyloid deposition in Alzheimer’s disease?. Curr Opin Investig Drugs, 2009, 10 (1), pp.46-55.
Keiflin R, Isingrini E, Cador M. Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties. Psychopharmacology (Berl), 2008, 197 (4), pp.649-60.
Gras C, Amilhon B, Lepicard EM, Poirel O, Vinatier J, Herbin M, Dumas S, Tzavara ET, Wade MR, Nomikos GG, Hanoun N, Saurini F, Kemel ML, Gasnier B, Giros B, El Mestikawy S. The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone. Nat Neurosci, 2008, 11 (3), pp.292-300.
Le Foll B, Diaz J, Sokoloff P. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Life Sci, 2005, 76 (11), pp.1281-96.
Le Foll B, Diaz J, Sokoloff P. A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning. Neuroreport, 2005, 16 (2), pp.175-8.
Guillin O, Griffon N, Diaz J, Le Foll B, Bezard E, Gross C, Lammers C, Stark H, Carroll P, Schwartz JC, Sokoloff P. Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway. Int Rev Neurobiol, 2004, 59, pp.425-44.
Leriche L, Diaz J, Sokoloff P. Dopamine and glutamate dysfunctions in schizophrenia: role of the dopamine D3 receptor. Neurotox Res, 2004, 6 (1), pp.63-71.
Francès H, Le Foll B, Diaz J, Smirnova M, Sokoloff P. Role of DRD3 in morphine-induced conditioned place preference using drd3-knockout mice. Neuroreport, 2004, 15 (14), pp.2245-9.
Nürnberger A, Räbiger M, Mack A, Diaz J, Sokoloff P, Mühlbauer B, Luippold G. Subapical localization of the dopamine D3 receptor in proximal tubules of the rat kidney. J Histochem Cytochem, 2004, 52 (12), pp.1647-55.
Herzog E, Landry M, Buhler E, Bouali-Benazzouz R, Legay C, Henderson CE, Nagy F, Dreyfus P, Giros B, El Mestikawy S. Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons. EMBO J, 2004.
Agulhon C, Rostaing P, Ravassard P, Sagné C, Triller A, Giros B. Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study. J Comp Neurol, 2003, 462 (1), pp.71-89.
Le Foll B, Diaz J, Sokoloff P. Increased dopamine D3 receptor expression accompanying behavioral sensitization to nicotine in rats. Synapse, 2003, 47 (3), pp.176-83.
Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain Res Mol Brain Res, 2003, 117 (1), pp.47-57.
Guillin O, Griffon N, Bezard E, Leriche L, Diaz J, Gross C, Sokoloff P. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson’s disease. Eur J Pharmacol, 2003, 480 (1-3), pp.89-95.
Derudder E, Laferté A, Ferreira V, Mishal Z, Baud V, Tarantino N, Körner M. Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2. Biochem Biophys Res Commun, 2003, 308 (4), pp.744-9.
Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, Baud V. RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem, 2003, 278 (26), pp.23278-84.
Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El Mestikawy S. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci, 2002, 22 (13), pp.5442-51.
Le Foll B, Francès H, Diaz J, Schwartz JC, Sokoloff P. Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice. Eur J Neurosci, 2002, 15 (12), pp.2016-26.
Sokoloff P, Guillin O, Diaz J, Carroll P, Griffon N. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: implications for neurodevelopmental psychiatric disorders. Neurotox Res, 2002, 4 (7-8), pp.671-678.
Sagné C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B. Identification and characterization of a lysosomal transporter for small neutral amino acids. Proc Natl Acad Sci U S A, 2001, 98 (13), pp.7206-11.
Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci, 2001, 21 (22), pp.RC181.
Cazes E, Giron-Michel J, Baouz S, Doucet C, Cagnoni F, Oddera S, Körner M, Dasic G, Testi R, Azzarone B, Canonica GW. Novel anti-inflammatory effects of the inhaled corticosteroid fluticasone propionate during lung myofibroblastic differentiation. J Immunol, 2001, 167 (9), pp.5329-37.
Denoyelle C, Vasse M, Körner M, Mishal Z, Ganné F, Vannier JP, Soria J, Soria C. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis, 2001, 22 (8), pp.1139-48.
Diaz J, Pilon C, Le Foll B, Gros C, Triller A, Schwartz JC, Sokoloff P. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci, 2000, 20 (23), pp.8677-84.
Schwartz JC, Diaz J, Pilon C, Sokoloff P. Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions. Brain Res Brain Res Rev, 2000, 31 (2-3), pp.277-87.
Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Dopamine D3 receptor gene expression in the shell of nucleus accumbens is increased by chronic antidepressant treatment. Mol Psychiatry, 2000, 5 (3), pp.229.
Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Mol Psychiatry, 2000, 5 (4), pp.378-88.
Schoonbroodt S, Ferreira V, Best-Belpomme M, Boelaert JR, Legrand-Poels S, Korner M, Piette J. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol, 2000, 164 (8), pp.4292-300.
Derudder E, Ferris, D K and Körner M. Phosphorylation of RelB during cellular activation. Biochimie, 1999, pp.252.
Ferreira V, Sidénius N, Tarantino N, Hubert P, Chatenoud L, Blasi F, Körner M. In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J Immunol, 1999, 162 (11), pp.6442-50.
Schwartz JC, Ridray S, Bordet R, Diaz J, Sokoloff P. D1/D3 receptor relationships in brain coexpression, coactivation, and coregulation. Adv Pharmacol, 1998, 42, pp.408-11.
Schwartz JC, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Sokoloff P. Functional implications of multiple dopamine receptor subtypes: the D1/D3 receptor coexistence. Brain Res Brain Res Rev, 1998, 26 (2-3), pp.236-42.
Ridray S, Griffon N, Mignon V, Souil E, Carboni S, Diaz J, Schwartz JC, Sokoloff P. Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions. Eur J Neurosci, 1998, 10 (5), pp.1676-86.
Sokoloff P, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Schwartz JC. [Function and therapeutic potential of the dopamine D3 receptor]. C R Seances Soc Biol Fil, 1998, 192 (6), pp.1111-25.
Asso-Bonnet M, Feuillard J, Ferreira V, Bissières P, Tarantino N, Körner M, Raphael M. Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells. Oncogene, 1998, 17 (12), pp.1607-15.
Ferreira V, Tarantino N, Körner M. Discrimination between RelA and RelB transcriptional regulation by a dominant negative mutant of IkappaBalpha. J Biol Chem, 1998, 273 (1), pp.592-9.
Sagné C, El Mestikawy S, Isambert MF, Hamon M, Henry JP, Giros B, Gasnier B. Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett, 1997, 417 (2), pp.177-83.
Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC. Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa. Proc Natl Acad Sci U S A, 1997, 94 (7), pp.3363-7.
Diaz J, Ridray S, Mignon V, Griffon N, Schwartz JC, Sokoloff P. Selective expression of dopamine D3 receptor mRNA in proliferative zones during embryonic development of the rat brain. J Neurosci, 1997, 17 (11), pp.4282-92.
Feuillard J, Dargemont C, Ferreira V, Tarantino N, Debré P, Raphael M, Körner M. Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes. J Immunol, 1997, 158 (6), pp.2585-91.
Cai Z, Körner M, Tarantino N, Chouaib S. IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis. J Biol Chem, 1997, 272 (1), pp.96-101.
Griffon N, Sautel F, Pilon C, Lévesque D, Sokoloff P, Schwartz JC, Diaz J, Simon P, Costentin J, Mann A, Wermuth CG. Functional models for the dopamine D3 receptor. Biochem Soc Trans, 1996, 24 (1), pp.193-8.
Cai Z, Stancou R, Körner M, Chouaib S. Impairment of Fas-antigen expression in adriamycin-resistant but not TNF-resistant MCF7 tumor cells. Int J Cancer, 1996, 68 (4), pp.535-46.
Feuillard J, Körner M, Israel A, Vassy J, Raphael M. Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ. Eur J Immunol, 1996, 26 (11), pp.2547-51.
Griffon N, Sokoloff P, Diaz J, Lévesque D, Sautel F, Schwartz JC, Simon P, Costentin J, Garrido F, Mann A. The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches. Eur Neuropsychopharmacol, 1995, 5 Suppl, pp.3-9.
Lévesque D, Martres MP, Diaz J, Griffon N, Lammers CH, Sokoloff P, Schwartz JC. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proc Natl Acad Sci U S A, 1995, 92 (5), pp.1719-23.
Diaz J, Lévesque D, Lammers CH, Griffon N, Martres MP, Schwartz JC, Sokoloff P. Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain. Neuroscience, 1995, 65 (3), pp.731-45.
Schwartz JC, Griffon N, Diaz J, Levesque D, Sautel F, Sokoloff P, Simon P, Costentin J, Garrido F, Mann A. The D3 receptor and its relevance in psychiatry. Int Clin Psychopharmacol, 1995, 10 Suppl 3, pp.15-20.
Hubert P, Bismuth G, Körner M, Debré P. HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. Eur J Immunol, 1995, 25 (5), pp.1417-25.
Schwartz JC, Diaz J, Griffon N, Levesque D, Martres MP, Sokoloff P. Multiple dopamine receptors: the D3 receptor and actions of substances of abuse. EXS, 1994, 71, pp.81-92.
Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P. Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem Biophys Res Commun, 1994, 200 (2), pp.1007-14.
Diaz J, Lévesque D, Griffon N, Lammers CH, Martres MP, Sokoloff P, Schwartz JC. Opposing roles for dopamine D2 and D3 receptors on neurotensin mRNA expression in nucleus accumbens. Eur J Neurosci, 1994, 6 (8), pp.1384-7.
Ouaaz F, Sola B, Issaly F, Kolb JP, Davi F, Mentz F, Arock M, Paul-Eugène N, Körner M, Dugas B. Growth arrest and terminal differentiation of leukemic myelomonocytic cells induced through ligation of surface CD23 antigen. Blood, 1994, 84 (9), pp.3095-104.
Li CC, Korner M, Ferris DK, Chen E, Dai RM, Longo DL. NF-kappa B/Rel family members are physically associated phosphoproteins. Biochem J, 1994, 303 ( Pt 2), pp.499-506.
Körner M, Tarantino N, Pleskoff O, Lee LM, Debré P. Activation of nuclear factor kappa B in human neuroblastoma cell lines. J Neurochem, 1994, 62 (5), pp.1716-26.
Tarantino N, Debré P, Körner M. Differential expression of PKC alpha and PKC beta isozymes in CD4+, CD8+ and CD4+/CD8+ double positive human T cells. FEBS Lett, 1994, 338 (3), pp.339-42.
Feuillard J, Körner M, Fourcade C, Costa A, Binet JL, Debré P, Raphael M. Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers. J Immunol, 1994, 152 (1), pp.12-21.
Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P. Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin. Proc Natl Acad Sci U S A, 1992, 89 (17), pp.8155-9.
Körner M, Tarantino N, Debré P. Constitutive activation of NF-kB in human thymocytes. Biochem Biophys Res Commun, 1991, 181 (1), pp.80-6.
Farrar WL, Korner M, Clouse KA. Cytokine regulation of human immunodeficiency virus expression. Cytokine, 1991, 3 (6), pp.531-42.
Feuillard J, Gouy H, Bismuth G, Lee LM, Debré P, Körner M. NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases. Cytokine, 1991, 3 (3), pp.257-65.
Korner M, Bellan AH, Brini AT, Farrar WL. Characterization of the human immunodeficiency virus type 1 enhancer-binding proteins from the human T-cell line Jurkat. Biochem J, 1990, 265 (2), pp.547-54.
Farrar WL, Brini AT, Harel-Bellan A, Korner M, Ferris DK. Hematopoietic growth-factor signal transduction and regulation of gene expression. Immunol Ser, 1990, 49, pp.379-410.
Harel-Bellan A, Korner M, Brini AT, Ferris D, Farrar WL. Activation of HIV-enhancer binding activity by mild detergents in human T cells. Biochem Biophys Res Commun, 1989, 162 (1), pp.238-43.
Brini AT, Harel-Bellan A, Korner M, Farrar WL. Detection of enhancer binding proteins recognizing the human immunodeficiency virus long terminal repeat by in situ gel retardation. Biochem Biophys Res Commun, 1989, 160 (1), pp.268-75.
Jankovic DL, Abehsira-Amar O, Korner M, Roth C, Hitoshi Y, Takatsu K, Theze J. IL-4, but not IL-5, can act synergistically with B cell activating factor (BCAF) to induce proliferation of resting B cells. Cell Immunol, 1988, 117 (1), pp.165-76.
Chatenoud L, Villemain F, Hoebeke J, Garbarg M, Korner M, Gros C, Ruat M, Cazenave PA, Ganellin CR, Bach JF. Polyclonal and monoclonal antibodies directed against SK & F 94461, a specific H1 histamine receptor ligand. Mol Pharmacol, 1988, 34 (2), pp.136-44.
Baran D, Korner M, Theze J. Characterization of the soluble murine IL-2R and estimation of its affinity for IL-2. J Immunol, 1988, 141 (2), pp.539-46.
Ruat M, Körner M, Garbarg M, Gros C, Schwartz JC, Tertiuk W, Ganellin CR. Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe. Proc Natl Acad Sci U S A, 1988, 85 (8), pp.2743-7.
Roth C, Moreau JL, Korner M, Jankovic D, Thèze J. Biochemical characterization and biological effects of partially purified B cell-activating factor (BCAF). Eur J Immunol, 1988, 18 (4), pp.577-84.
Blakemore RC Ganellin CR, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, Colin, and Theobald J. Iodobolpyramine and other iodinated derivatives as ligands for detecting Histamine H1 receptors. Eur J Med Chem, 1987, 22 (March), pp.91-100.
Schwartz JC, Arrang JM, Garbarg M, Korner M. Properties and roles of the three subclasses of histamine receptors in brain. J Exp Biol, 1986, 124, pp.203-24.
Korner M, Bouthenet ML, Ganellin CR, Garbarg M, Gros C, Ife RJ, Sales N, Schwartz JC. [125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain. Eur J Pharmacol, 1986, 120 (2), pp.151-60.
Körner M, Van Thiem N, Cardinaud R, Lacombe G. Location of an essential carboxyl group along the heavy chain of cardiac and skeletal myosin subfragments 1. Biochemistry, 1983, 22 (25), pp.5843-7.
Körner M, Van Thiem N, Lacombe G, Swynghedauw B. Cardiac myosin subfragment 1 modification by carbodiimide in the presence of a nucleophile. Biochem Biophys Res Commun, 1982, 105 (3), pp.1198-207.

Chapters

Farrar WL, Körner M, Brini A, Harel-Bellan A, and Ferris D. Hematopoietic Growth-Factors Signal Transduction and Regulation of Gene Expression. Molecular Hematology, Chapter 14, Garland J - Eds. M. Dexter and J. Garland Elsvier Publishers, London, pp.379-410, 1989.
Farrar WL, Körner M, and Brini A. The role of Calcium in Cellular Proliferation. The Role of Calcium in Biological Systems, Farrar WL - Eds. L. Anghitevi, CRC Press Boca Raton Pb., pp.239-252, 1989.
Abehsira-Amar O, Jankovic DL, Körner M, and Thèze J. Influence of IL-4 on the induction of immunoglobulin secretion by BCAF-containing supernatant. Lymphocyte activation and Differentiation, Thèze J - Walter de Gruyter & Co., Berlin, 1988.
Ganellin CR, Boutenet ML, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, and Theobald CJ. Iodinated Ligands for detecting and characterizing Histamine H1 receptors. Proceedings of the 10th international symposium on Medicinal Chemistry, L Palosand, H Timmerman - Elsvier Publisher, 1988.
Garbarg M, Yeramian E, Korner M, Schwartz JC. Biochemical studies of cerebral H1-receptors. Frontiers in histamine research, Ganelin CR, Schwartz JC - Frontiers in histamine research. Oxford: Pergamon Press, pp.19-25, 1985.
Garbard M, Yeramian E, Körner M, and Schwartz J-C. Biochemical studies of cerebral H1-receptors. Frontiers in Histamine Research, CR Ganellin and J-C Schwartz - Pergamon Press (Oxford), pp.19-25, 1985.

PATHOPHYSIOLOGY OF PSYCHIATRIC DISORDERS GROUP

RESEARCH TOPICS ︾

Theme 1: Etiology of depression
- Development of biomarkers in humans to assess the efficacy of antidepressant therapies
Theme 2: Dopamine hypothesis and pathophysiology of schizophrenia
- Dopamine transporter (DAT) interactome and proteome
characterizing DA dynamics in cortical areas

TEAM MEMBERS

Permanent researchers

Bruno GIROS

Team leader

Jorge DIAZ

MCF

Team leader

Stéphanie DE GOIS

IR CNRS

Elsa ISINGRINI

CR CNRS

Post docs, PhD & Master students

Déa SLAVOVA

PhD student

Gurvan LE LAY

M2 student

Maud BLAISE

M1 student

PUBLICATIONS ︾

Articles

Orrico-Sanchez A, Chausset-Boissarie L, Alves de Sousa R, Coutens B, Rezai Amin S, Vialou V, Louis F, Hessani A, Dansette PM, Zornoza T, Gruszczynski C, Giros B, Guiard BP, Acher F, Pietrancosta N, Gautron S. Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression. Mol Psychiatry, 2020, 25 (6), pp.1245-1259.
Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N. LSP5-2157 a new inhibitor of vesicular glutamate transporters. Neuropharmacology, 2020, 164, pp.107902.
Laboute T, Gandía J, Pellissier LP, Corde Y, Rebeillard F, Gallo M, Gauthier C, Léauté A, Diaz J, Poupon A, Kieffer BL, Le Merrer J, Becker JA. The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs. Elife, 2020, 9.
Diaz J, Gérard X, Emerit MB, Areias J, Geny D, Dégardin J, Simonutti M, Guerquin MJ, Collin T, Viollet C, Billard JM, Métin C, Hubert L, Larti F, Kahrizi K, Jobling R, Agolini E, Shaheen R, Zigler A, Rouiller-Fabre V, Rozet JM, Picaud S, Novelli A, Alameer S, Najmabadi H, Cohn R, Munnich A, Barth M, Lugli L, Alkuraya FS, Blaser S, Gashlan M, Besmond C, Darmon M, Masson J. YIF1B mutations cause a post-natal neurodevelopmental syndrome associated with Golgi and primary cilium alterations. Brain, 2020, 143 (10), pp.2911-2928.
Hernandez G, Mahmoudi S, Cyr M, Diaz J, Blanchet PJ, Lévesque D. Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates. Mov Disord, 2019, 34 (5), pp.717-726.
Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET. Antidepressive effects of targeting ELK-1 signal transduction. Nat Med, 2018, 24 (5), pp.591-597.
Isingrini E, Guinaudie C, C Perret L, Rainer Q, Moquin L, Gratton A, Giros B. Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice. Sci Rep, 2017, 7 (1), pp.12432.
Mahar I, Labonte B, Yogendran S, Isingrini E, Perret L, Davoli MA, Rachalski A, Giros B, Turecki G, Mechawar N. Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Transl Psychiatry, 2017, 7 (7), pp.e1161.
Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. ENeuro, 2017, 4 (3).
Moinard C, Tliba L, Diaz J, Le Plénier S, Nay L, Neveux N, Cynober L, Raynaud-Simon A. Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway. Nutrition, 2017, 38, pp.9-12.
Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S. Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells. Front Cell Neurosci, 2017, 11, pp.140.
Emerit MB, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, Masson J, Boué-Grabot E, Darmon M. A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels. J Neurosci, 2016, 36 (5), pp.1456-70.
Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B. Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nat Neurosci, 2016, 19 (4), pp.560-3.
Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA. Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biol Psychiatry, 2016, 79 (11), pp.917-27.
Doly S, Shirvani H, Gäta G, Meye FJ, Emerit MB, Enslen H, Achour L, Pardo-Lopez L, Yang SK, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M, Marullo S. GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper. Mol Psychiatry, 2016, 21 (4), pp.480-90.
Herbin M, Simonis C, Revéret L, Hackert R, Libourel PA, Eugène D, Diaz J, de Waele C, Vidal PP. Dopamine Modulates Motor Control in a Specific Plane Related to Support. PLoS One, 2016.
Rocchetti J, Isingrini E, Dal Bo G, Sagheby S, Menegaux A, Tronche F, Levesque D, Moquin L, Gratton A, Wong TP, Rubinstein M, Giros B. Presynaptic D2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. Biol Psychiatry, 2015, 77 (6), pp.513-25.
Martel G, Simon A, Nocera S, Kalainathan S, Pidoux L, Blum D, Leclère-Turbant S, Diaz J, Geny D, Moyse E, Videau C, Buée L, Epelbaum J, Viollet C. Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice. Neurobiol Aging, 2015, 36 (2), pp.1013-28.
Alterio J, Masson J, Diaz J, Chachlaki K, Salman H, Areias J, Al Awabdh S, Emerit MB, Darmon M. Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture. Traffic, 2015, 16 (9), pp.978-93.
Khaled MA, Pushparaj A, Di Ciano P, Diaz J, Le Foll B. Dopamine D3 receptors in the basolateral amygdala and the lateral habenula modulate cue-induced reinstatement of nicotine seeking. Neuropsychopharmacology, 2014, 39 (13), pp.3049-58.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386 (2), pp.107-24.
Isingrini E, Belzung C, Freslon JL, Machet MC, Camus V. Fluoxetine effect on aortic nitric oxide-dependent vasorelaxation in the unpredictable chronic mild stress model of depression in mice. Psychosom Med, 2012, 74 (1), pp.63-72.
Isingrini E, Belzung C, d’Audiffret A, Camus V. Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging. Am J Geriatr Psychiatry, 2011, 19 (4), pp.335-46.
Narboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R. Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology, 2011, 36 (12), pp.2538-50. (PDF)
Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM. Polarized Secretion of Lysosomes at the B Cell Synapse couples Antigen Extraction to Processing and Presentation. Immunity, 2011.
Pietrancosta N, Kessler A, Favre-Besse F-C, Triballeau N, Quentin T, Giros B, El Mestikawy S, Acher F C. Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorganic \& medicinal chemistry, 2010, 18, pp.6922--6933.
Isingrini E, Camus V, Le Guisquet AM, Pingaud M, Devers S, Belzung C. Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice. PLoS One, 2010, 5 (4), pp.e10404.
d’Audiffret AC, Frisbee SJ, Stapleton PA, Goodwill AG, Isingrini E, Frisbee JC. Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?. J Appl Physiol (1985), 2010, 108 (5), pp.1041-51.
Amilhon B, Lepicard E, Renoir T, Mongeau R, Popa D, Poirel O, Miot S, Gras C, Gardier AM, Gallego J, Hamon M, Lanfumey L, Gasnier B, Giros B, El Mestikawy S. VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. J Neurosci, 2010, 30 (6), pp.2198-210. (PDF)
Isingrini E, Desmidt T, Belzung C, Camus V. Endothelial dysfunction: A potential therapeutic target for geriatric depression and brain amyloid deposition in Alzheimer’s disease?. Curr Opin Investig Drugs, 2009, 10 (1), pp.46-55.
Keiflin R, Isingrini E, Cador M. Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties. Psychopharmacology (Berl), 2008, 197 (4), pp.649-60.
Gras C, Amilhon B, Lepicard EM, Poirel O, Vinatier J, Herbin M, Dumas S, Tzavara ET, Wade MR, Nomikos GG, Hanoun N, Saurini F, Kemel ML, Gasnier B, Giros B, El Mestikawy S. The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone. Nat Neurosci, 2008, 11 (3), pp.292-300.
Le Foll B, Diaz J, Sokoloff P. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Life Sci, 2005, 76 (11), pp.1281-96.
Le Foll B, Diaz J, Sokoloff P. A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning. Neuroreport, 2005, 16 (2), pp.175-8.
Guillin O, Griffon N, Diaz J, Le Foll B, Bezard E, Gross C, Lammers C, Stark H, Carroll P, Schwartz JC, Sokoloff P. Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway. Int Rev Neurobiol, 2004, 59, pp.425-44.
Leriche L, Diaz J, Sokoloff P. Dopamine and glutamate dysfunctions in schizophrenia: role of the dopamine D3 receptor. Neurotox Res, 2004, 6 (1), pp.63-71.
Francès H, Le Foll B, Diaz J, Smirnova M, Sokoloff P. Role of DRD3 in morphine-induced conditioned place preference using drd3-knockout mice. Neuroreport, 2004, 15 (14), pp.2245-9.
Nürnberger A, Räbiger M, Mack A, Diaz J, Sokoloff P, Mühlbauer B, Luippold G. Subapical localization of the dopamine D3 receptor in proximal tubules of the rat kidney. J Histochem Cytochem, 2004, 52 (12), pp.1647-55.
Herzog E, Landry M, Buhler E, Bouali-Benazzouz R, Legay C, Henderson CE, Nagy F, Dreyfus P, Giros B, El Mestikawy S. Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons. EMBO J, 2004.
Agulhon C, Rostaing P, Ravassard P, Sagné C, Triller A, Giros B. Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study. J Comp Neurol, 2003, 462 (1), pp.71-89.
Le Foll B, Diaz J, Sokoloff P. Increased dopamine D3 receptor expression accompanying behavioral sensitization to nicotine in rats. Synapse, 2003, 47 (3), pp.176-83.
Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain Res Mol Brain Res, 2003, 117 (1), pp.47-57.
Guillin O, Griffon N, Bezard E, Leriche L, Diaz J, Gross C, Sokoloff P. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson’s disease. Eur J Pharmacol, 2003, 480 (1-3), pp.89-95.
Derudder E, Laferté A, Ferreira V, Mishal Z, Baud V, Tarantino N, Körner M. Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2. Biochem Biophys Res Commun, 2003, 308 (4), pp.744-9.
Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, Baud V. RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem, 2003, 278 (26), pp.23278-84.
Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El Mestikawy S. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci, 2002, 22 (13), pp.5442-51.
Le Foll B, Francès H, Diaz J, Schwartz JC, Sokoloff P. Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice. Eur J Neurosci, 2002, 15 (12), pp.2016-26.
Sokoloff P, Guillin O, Diaz J, Carroll P, Griffon N. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: implications for neurodevelopmental psychiatric disorders. Neurotox Res, 2002, 4 (7-8), pp.671-678.
Sagné C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B. Identification and characterization of a lysosomal transporter for small neutral amino acids. Proc Natl Acad Sci U S A, 2001, 98 (13), pp.7206-11.
Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci, 2001, 21 (22), pp.RC181.
Cazes E, Giron-Michel J, Baouz S, Doucet C, Cagnoni F, Oddera S, Körner M, Dasic G, Testi R, Azzarone B, Canonica GW. Novel anti-inflammatory effects of the inhaled corticosteroid fluticasone propionate during lung myofibroblastic differentiation. J Immunol, 2001, 167 (9), pp.5329-37.
Denoyelle C, Vasse M, Körner M, Mishal Z, Ganné F, Vannier JP, Soria J, Soria C. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis, 2001, 22 (8), pp.1139-48.
Diaz J, Pilon C, Le Foll B, Gros C, Triller A, Schwartz JC, Sokoloff P. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci, 2000, 20 (23), pp.8677-84.
Schwartz JC, Diaz J, Pilon C, Sokoloff P. Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions. Brain Res Brain Res Rev, 2000, 31 (2-3), pp.277-87.
Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Dopamine D3 receptor gene expression in the shell of nucleus accumbens is increased by chronic antidepressant treatment. Mol Psychiatry, 2000, 5 (3), pp.229.
Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Mol Psychiatry, 2000, 5 (4), pp.378-88.
Schoonbroodt S, Ferreira V, Best-Belpomme M, Boelaert JR, Legrand-Poels S, Korner M, Piette J. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol, 2000, 164 (8), pp.4292-300.
Derudder E, Ferris, D K and Körner M. Phosphorylation of RelB during cellular activation. Biochimie, 1999, pp.252.
Ferreira V, Sidénius N, Tarantino N, Hubert P, Chatenoud L, Blasi F, Körner M. In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J Immunol, 1999, 162 (11), pp.6442-50.
Schwartz JC, Ridray S, Bordet R, Diaz J, Sokoloff P. D1/D3 receptor relationships in brain coexpression, coactivation, and coregulation. Adv Pharmacol, 1998, 42, pp.408-11.
Schwartz JC, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Sokoloff P. Functional implications of multiple dopamine receptor subtypes: the D1/D3 receptor coexistence. Brain Res Brain Res Rev, 1998, 26 (2-3), pp.236-42.
Ridray S, Griffon N, Mignon V, Souil E, Carboni S, Diaz J, Schwartz JC, Sokoloff P. Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions. Eur J Neurosci, 1998, 10 (5), pp.1676-86.
Sokoloff P, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Schwartz JC. [Function and therapeutic potential of the dopamine D3 receptor]. C R Seances Soc Biol Fil, 1998, 192 (6), pp.1111-25.
Asso-Bonnet M, Feuillard J, Ferreira V, Bissières P, Tarantino N, Körner M, Raphael M. Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells. Oncogene, 1998, 17 (12), pp.1607-15.
Ferreira V, Tarantino N, Körner M. Discrimination between RelA and RelB transcriptional regulation by a dominant negative mutant of IkappaBalpha. J Biol Chem, 1998, 273 (1), pp.592-9.
Sagné C, El Mestikawy S, Isambert MF, Hamon M, Henry JP, Giros B, Gasnier B. Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett, 1997, 417 (2), pp.177-83.
Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC. Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa. Proc Natl Acad Sci U S A, 1997, 94 (7), pp.3363-7.
Diaz J, Ridray S, Mignon V, Griffon N, Schwartz JC, Sokoloff P. Selective expression of dopamine D3 receptor mRNA in proliferative zones during embryonic development of the rat brain. J Neurosci, 1997, 17 (11), pp.4282-92.
Feuillard J, Dargemont C, Ferreira V, Tarantino N, Debré P, Raphael M, Körner M. Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes. J Immunol, 1997, 158 (6), pp.2585-91.
Cai Z, Körner M, Tarantino N, Chouaib S. IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis. J Biol Chem, 1997, 272 (1), pp.96-101.
Griffon N, Sautel F, Pilon C, Lévesque D, Sokoloff P, Schwartz JC, Diaz J, Simon P, Costentin J, Mann A, Wermuth CG. Functional models for the dopamine D3 receptor. Biochem Soc Trans, 1996, 24 (1), pp.193-8.
Cai Z, Stancou R, Körner M, Chouaib S. Impairment of Fas-antigen expression in adriamycin-resistant but not TNF-resistant MCF7 tumor cells. Int J Cancer, 1996, 68 (4), pp.535-46.
Feuillard J, Körner M, Israel A, Vassy J, Raphael M. Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ. Eur J Immunol, 1996, 26 (11), pp.2547-51.
Griffon N, Sokoloff P, Diaz J, Lévesque D, Sautel F, Schwartz JC, Simon P, Costentin J, Garrido F, Mann A. The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches. Eur Neuropsychopharmacol, 1995, 5 Suppl, pp.3-9.
Lévesque D, Martres MP, Diaz J, Griffon N, Lammers CH, Sokoloff P, Schwartz JC. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proc Natl Acad Sci U S A, 1995, 92 (5), pp.1719-23.
Diaz J, Lévesque D, Lammers CH, Griffon N, Martres MP, Schwartz JC, Sokoloff P. Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain. Neuroscience, 1995, 65 (3), pp.731-45.
Schwartz JC, Griffon N, Diaz J, Levesque D, Sautel F, Sokoloff P, Simon P, Costentin J, Garrido F, Mann A. The D3 receptor and its relevance in psychiatry. Int Clin Psychopharmacol, 1995, 10 Suppl 3, pp.15-20.
Hubert P, Bismuth G, Körner M, Debré P. HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. Eur J Immunol, 1995, 25 (5), pp.1417-25.
Schwartz JC, Diaz J, Griffon N, Levesque D, Martres MP, Sokoloff P. Multiple dopamine receptors: the D3 receptor and actions of substances of abuse. EXS, 1994, 71, pp.81-92.
Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P. Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem Biophys Res Commun, 1994, 200 (2), pp.1007-14.
Diaz J, Lévesque D, Griffon N, Lammers CH, Martres MP, Sokoloff P, Schwartz JC. Opposing roles for dopamine D2 and D3 receptors on neurotensin mRNA expression in nucleus accumbens. Eur J Neurosci, 1994, 6 (8), pp.1384-7.
Ouaaz F, Sola B, Issaly F, Kolb JP, Davi F, Mentz F, Arock M, Paul-Eugène N, Körner M, Dugas B. Growth arrest and terminal differentiation of leukemic myelomonocytic cells induced through ligation of surface CD23 antigen. Blood, 1994, 84 (9), pp.3095-104.
Li CC, Korner M, Ferris DK, Chen E, Dai RM, Longo DL. NF-kappa B/Rel family members are physically associated phosphoproteins. Biochem J, 1994, 303 ( Pt 2), pp.499-506.
Körner M, Tarantino N, Pleskoff O, Lee LM, Debré P. Activation of nuclear factor kappa B in human neuroblastoma cell lines. J Neurochem, 1994, 62 (5), pp.1716-26.
Tarantino N, Debré P, Körner M. Differential expression of PKC alpha and PKC beta isozymes in CD4+, CD8+ and CD4+/CD8+ double positive human T cells. FEBS Lett, 1994, 338 (3), pp.339-42.
Feuillard J, Körner M, Fourcade C, Costa A, Binet JL, Debré P, Raphael M. Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers. J Immunol, 1994, 152 (1), pp.12-21.
Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P. Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin. Proc Natl Acad Sci U S A, 1992, 89 (17), pp.8155-9.
Körner M, Tarantino N, Debré P. Constitutive activation of NF-kB in human thymocytes. Biochem Biophys Res Commun, 1991, 181 (1), pp.80-6.
Farrar WL, Korner M, Clouse KA. Cytokine regulation of human immunodeficiency virus expression. Cytokine, 1991, 3 (6), pp.531-42.
Feuillard J, Gouy H, Bismuth G, Lee LM, Debré P, Körner M. NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases. Cytokine, 1991, 3 (3), pp.257-65.
Korner M, Bellan AH, Brini AT, Farrar WL. Characterization of the human immunodeficiency virus type 1 enhancer-binding proteins from the human T-cell line Jurkat. Biochem J, 1990, 265 (2), pp.547-54.
Farrar WL, Brini AT, Harel-Bellan A, Korner M, Ferris DK. Hematopoietic growth-factor signal transduction and regulation of gene expression. Immunol Ser, 1990, 49, pp.379-410.
Harel-Bellan A, Korner M, Brini AT, Ferris D, Farrar WL. Activation of HIV-enhancer binding activity by mild detergents in human T cells. Biochem Biophys Res Commun, 1989, 162 (1), pp.238-43.
Brini AT, Harel-Bellan A, Korner M, Farrar WL. Detection of enhancer binding proteins recognizing the human immunodeficiency virus long terminal repeat by in situ gel retardation. Biochem Biophys Res Commun, 1989, 160 (1), pp.268-75.
Jankovic DL, Abehsira-Amar O, Korner M, Roth C, Hitoshi Y, Takatsu K, Theze J. IL-4, but not IL-5, can act synergistically with B cell activating factor (BCAF) to induce proliferation of resting B cells. Cell Immunol, 1988, 117 (1), pp.165-76.
Chatenoud L, Villemain F, Hoebeke J, Garbarg M, Korner M, Gros C, Ruat M, Cazenave PA, Ganellin CR, Bach JF. Polyclonal and monoclonal antibodies directed against SK & F 94461, a specific H1 histamine receptor ligand. Mol Pharmacol, 1988, 34 (2), pp.136-44.
Baran D, Korner M, Theze J. Characterization of the soluble murine IL-2R and estimation of its affinity for IL-2. J Immunol, 1988, 141 (2), pp.539-46.
Ruat M, Körner M, Garbarg M, Gros C, Schwartz JC, Tertiuk W, Ganellin CR. Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe. Proc Natl Acad Sci U S A, 1988, 85 (8), pp.2743-7.
Roth C, Moreau JL, Korner M, Jankovic D, Thèze J. Biochemical characterization and biological effects of partially purified B cell-activating factor (BCAF). Eur J Immunol, 1988, 18 (4), pp.577-84.
Blakemore RC Ganellin CR, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, Colin, and Theobald J. Iodobolpyramine and other iodinated derivatives as ligands for detecting Histamine H1 receptors. Eur J Med Chem, 1987, 22 (March), pp.91-100.
Schwartz JC, Arrang JM, Garbarg M, Korner M. Properties and roles of the three subclasses of histamine receptors in brain. J Exp Biol, 1986, 124, pp.203-24.
Korner M, Bouthenet ML, Ganellin CR, Garbarg M, Gros C, Ife RJ, Sales N, Schwartz JC. [125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain. Eur J Pharmacol, 1986, 120 (2), pp.151-60.
Körner M, Van Thiem N, Cardinaud R, Lacombe G. Location of an essential carboxyl group along the heavy chain of cardiac and skeletal myosin subfragments 1. Biochemistry, 1983, 22 (25), pp.5843-7.
Körner M, Van Thiem N, Lacombe G, Swynghedauw B. Cardiac myosin subfragment 1 modification by carbodiimide in the presence of a nucleophile. Biochem Biophys Res Commun, 1982, 105 (3), pp.1198-207.

Chapters

Farrar WL, Körner M, Brini A, Harel-Bellan A, and Ferris D. Hematopoietic Growth-Factors Signal Transduction and Regulation of Gene Expression. Molecular Hematology, Chapter 14, Garland J - Eds. M. Dexter and J. Garland Elsvier Publishers, London, pp.379-410, 1989.
Farrar WL, Körner M, and Brini A. The role of Calcium in Cellular Proliferation. The Role of Calcium in Biological Systems, Farrar WL - Eds. L. Anghitevi, CRC Press Boca Raton Pb., pp.239-252, 1989.
Abehsira-Amar O, Jankovic DL, Körner M, and Thèze J. Influence of IL-4 on the induction of immunoglobulin secretion by BCAF-containing supernatant. Lymphocyte activation and Differentiation, Thèze J - Walter de Gruyter & Co., Berlin, 1988.
Ganellin CR, Boutenet ML, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, and Theobald CJ. Iodinated Ligands for detecting and characterizing Histamine H1 receptors. Proceedings of the 10th international symposium on Medicinal Chemistry, L Palosand, H Timmerman - Elsvier Publisher, 1988.
Garbarg M, Yeramian E, Korner M, Schwartz JC. Biochemical studies of cerebral H1-receptors. Frontiers in histamine research, Ganelin CR, Schwartz JC - Frontiers in histamine research. Oxford: Pergamon Press, pp.19-25, 1985.
Garbard M, Yeramian E, Körner M, and Schwartz J-C. Biochemical studies of cerebral H1-receptors. Frontiers in Histamine Research, CR Ganellin and J-C Schwartz - Pergamon Press (Oxford), pp.19-25, 1985.