Translational psychopharmacology: Novel Targets and Biomarkers

Psychiatric disorder management and care has entered a new development cycle towards a personalized medicine era. In this context, research in the Translational psychopharmacology: Novel Targets and Biomarkers aims to promote innovation and continuous exchange with shareholders and stakeholders towards patented novel pharmacological, predictive and prognostic approaches in psychiatry. Spanning from bench to bedside our research -is driven from our recent breakthrough work on novel targets and biomarkers (Nature Medicine, 2018; Nature Communications, 2020), -builds strong collaborative networks bringing together (i) innovative preclinical animal models, (ii) imaging (MRI, spectroscopy), (iii) coding and non-coding RNAs, (iv) bioinformatics, and -leads national (Paris Saclay-IMAGEN, AP-HP, Aix-Marseille Univ, AP-HM, CHU St Etienne) and international (PRBB/IMIM/Barcelona and Univ Basque Country/Bilbao, Spain; McGill, Canada; BROAD/McLean and Univ New Mexico, USA) multidisciplinary Consortia.

Research topics
  • Theme 1: Imaging gene and brain networks in stress susceptibility (GeBra); 
  • Theme 2: Deciphering neurotransmitter vulnerability in schizophrenic patients (SchiDOTab);
  • Theme 3: Linking distorted cellular signaling with distorted executive processing in schizophrenia (EXEcute);
  • Theme 4: Biomarkers of antidepressant response ; early indicators and novel targets (ANTaRES).

TEAM MEMBERS

Permanent researchers

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Dr. Eleni Tzavara

DR INSERM
Translational psychopharmacology: Novel Targets and Biomarkers

Post docs, PhD and Master students

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Dr. Victor Gorgievski

Senior Engineer
Translational psychopharmacology: Novel Targets and Biomarkers

︾ PUBLICATIONS ︾

Article

  • Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET. Antidepressive effects of targeting ELK-1 signal transduction. Nat Med, 2018, 24 (5), pp.591-597.