PATHOPHYSIOLOGY OF PSYCHIATRIC DISORDERS GROUP

Research conducted by the Pathophysiology of Psychiatric Disorders team aims to answer two major questions : the Etiology of Depression, and the function of Dopamine in  the pathophysiology of schizophrenia.

Our fundamental and preclinical studies have identified new mechanisms contributing to individual vulnerability or resistance (resiliency) to depression and underlying the action of antidepressants. Ongoing projects aim to further elucidate the role of these novel systems in plasticity-related processes within the neural circuitry in normal and pathological conditions. We will also investigate whether certain of these systems constitute valid biomarkers in humans, to assess the efficacy of antidepressant therapies, and we are currently developing selective approaches to manipulate their activity in order to improve antidepressant efficacy.

Research topics

Theme 1: Etiology of depression
– Neural networks in vulnerability and resiliance to depression

Theme 2: Dopamine hypothesis and pathophysiology of schizophrenia
– Dopamine transporter (DAT) interactome and proteome
characterizing DA dynamics in cortical areas

– Functional diversity  of dopaminoceptive Medium Spiny Neurons

Functional diversity of dopaminoceptive  Medium Spiny Neurons

 

TEAM MEMBERS

Permanent researchers

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Dr. Jorge Diaz

Assistant Professor - Emeritus
Pathophysiology of psychiatric disorders

Support staff

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Post docs, PhD and Master students

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Dr. Vanessa Ortiz

Postdoctoral Researcher
Pathophysiology of psychiatric disorders

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Integrative Neuroscience and Cognition Center - CNRS UMR 8002
CNRS, Université de Paris
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 XX XX

Maud BLAISE

Doctoral Student
Pathophysiology of psychiatric disorders

︾ PUBLICATIONS ︾

Articles

Chapters

  • Farrar WL, Körner M, Brini A, Harel-Bellan A, and Ferris D. Hematopoietic Growth-Factors Signal Transduction and Regulation of Gene Expression. Molecular Hematology, Chapter 14, Garland J - Eds. M. Dexter and J. Garland Elsvier Publishers, London, pp.379-410, 1989.
  • Farrar WL, Körner M, and Brini A. The role of Calcium in Cellular Proliferation. The Role of Calcium in Biological Systems, Farrar WL - Eds. L. Anghitevi, CRC Press Boca Raton Pb., pp.239-252, 1989.
  • Abehsira-Amar O, Jankovic DL, Körner M, and Thèze J. Influence of IL-4 on the induction of immunoglobulin secretion by BCAF-containing supernatant. Lymphocyte activation and Differentiation, Thèze J - Walter de Gruyter & Co., Berlin, 1988.
  • Ganellin CR, Boutenet ML, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz J-C, Tertiuk W, and Theobald CJ. Iodinated Ligands for detecting and characterizing Histamine H1 receptors. Proceedings of the 10th international symposium on Medicinal Chemistry, L Palosand, H Timmerman - Elsvier Publisher, 1988.
  • Garbarg M, Yeramian E, Korner M, Schwartz JC. Biochemical studies of cerebral H1-receptors. Frontiers in histamine research, Ganelin CR, Schwartz JC - Frontiers in histamine research. Oxford: Pergamon Press, pp.19-25, 1985.
  • Garbard M, Yeramian E, Körner M, and Schwartz J-C. Biochemical studies of cerebral H1-receptors. Frontiers in Histamine Research, CR Ganellin and J-C Schwartz - Pergamon Press (Oxford), pp.19-25, 1985.