Naguib MechawarProfessor of Psychiatry, McGill University, Canada
Early-life adversity and its long-term influence on cerebral ologodendrocytes and myélination, by Naguib Mechawar
Early-life adversity can have devastating and lasting consequences on individuals, considerably increasing the lifetime risk of negative mental health outcomes such as depression and suicide. Yet, the neurobiological processes underlying this increase in vulnerability remain poorly understood. I will present some of our recent work, conducted with wellcharacterized post-mortem brain samples, indicating that child abuse, in part through epigenetic reprogramming of oligodendrocytes, may lastingly disrupt cortical myelination, a fundamental feature of cerebral connectivity.
Naguib Mechawar, PhD, joined the Douglas Institute and the McGill Group for Suicide Studies in 2007. He is mainly interested in identifying the neurochemical and neuroanatomical properties underlying major depression and suicide. His research is focused on limbic brain regions.