Organizer

Cendra Agulhon
Email
cendra.agulhon@parisdescartes.fr

Other Organizers

Bruna Rubino
Email
bruna.rubino@parisdescartes.fr

Speakers

Location

Conference room R229
Centre Universitaire des Saints Pères
QR Code

Date

Nov 22 2019

Time

11 h 30 min - 12 h 30 min

Labels

Neuroscience Seminar Series

Neocortical dynamics during sensory discrimination behavior, by Fritjof Helmchen

Summary:

Through the combination of in vivo optical imaging and chronic expression of genetically encoded calcium indicators it is now feasible to directly ‘watch’ neuronal population dynamics in the neocortex of awake, head-restrained mice during specific behaviors. Here, I will present results from calcium imaging experiments in mouse neocortex while the animals perform whisker-based or auditory sensory discrimination tasks. We used wide-field calcium imaging to resolve spatiotemporal activation patterns across large parts of the neocortex during individual trials. We also chronically monitored cortical dynamics over weeks and across task learning. We observed wide-spread, coordinated activation of multiple cortical areas, which correlated with various behavioral aspects such as whisking, body movements, and licking. In particular, we identified highly distinct patterns of persistent cortical activity during a short-term memory phase, which were contingent of the animal’s behavior (active versus passive). We also found that posterior parietal cortex (PPC) presumably acts as a routing hub, with distinct subdivisions being activated for tactile versus auditory discriminations. During learning we identified two salient phases framing the effective learning period, which in particular reorganized the signal flow through posterior association areas, including PPC. Our results contribute to the understanding of the principles of large-scale activation patterns supporting sensory discrimination and of how these
patterns emerge during learning.

More information at the INC website

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